Back to results
US 2014/0235488 A1Published application
Microrna patterns for the diagnosis, prognosis and treatment of melanoma
AssigneesTel HaShomer Medical Research Infrastructure and Services Ltd., Ramot at Tel-Aviv University Ltd.
InventorsGal Markel, Eyal Greenberg, Noam Shomron, Liat Edry, Jacob Schachter
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof.
Claims8
A method for diagnosing melanoma in a subject, comprising:
- (a) obtaining from the subject a sample of peripheral blood comprising RNA;
- and
- (b) determining, in said RNA, the presence of a plurality of oncogenic miRNAs, comprising miRNAs selected from the group consisting of:
- miR-374a, miR-301a, SNORD-38b, miR-29c, miR-324-3p, miR-451 and miR-29a,
- wherein the presence of the plurality of oncogenic miRs is indicative of the subject having, or being susceptible to developing melanoma.
2 more elements
A method of determining responsiveness of a patient diagnosed with melanoma to drug therapy, comprising;
- (a) obtaining a sample comprising RNA from a subject diagnosed with melanoma;
- and
- (b) determining, in said RNA, the presence of a plurality of response associated miRs,
- wherein the presence of at least one response associated miR is indicative of a positive outcome to the treatment.
1 more element
Dependencies are inferred from the claim text.