Signatures and pcdeterminants associated with prostate cancer and methods of use thereof
OwnerRonald A. Depinho, Zhihu Ding +1inventors
InventorsRonald A. Depinho, Zhihu Ding, Lynda Chin
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Abstract
The present invention provides methods of detecting cancer using biomarkers.
Claims20
A method with a predetermined level of predictability for assessing a risk of cancer
- recurrence or development of a metastatic cancer in a subject comprising:
- a. measuring the level of two or more PCDETERMINANTS selected from the group consisting of PCDETERMINANTS 1-372 in a sample from the subject, and
- b. measuring a clinically significant alteration in the level of the two or more PCDETERMINANTS in the sample, wherein the alteration indicates an increased risk of cancer recurrence or developing metastatic cancer in the subject.
11-13. (canceled)
A method with a predetermined level of predictability for assessing the progression of a tumor in a subject, for monitoring the effectiveness of a treatment for a recurrent or a metastatic cancer in a subject, or for selecting a treatment regimen for a subject diagnosed with a tumor, the method comprising:
- a. detecting the level of two or more PCDETERMINANTS selected from the group consisting of PCDETERMINANTS 1-372 in a first sample from the subject at a first period of time;
- b. detecting the level of two or more PCDETERMINANTS in a second sample from the subject at a second period of time;
- c. comparing the level of the two or more PCDETERMINANTS detected in step (a) to the level detected in step (b), or to a reference value.
15-26. (canceled)
A metastatic prostate cancer reference expression profile, comprising a pattern of marker levels of two or more markers selected from the group consisting of PCDETERMINANTS 1-372.
29-32. (canceled)
A PCDETERMINANT panel comprising one or more PCDETERMINANTS that are indicative of a physiological or biochemical pathway associated metastasis or that are indicative of the progression of a tumor.
34-57. (canceled)
Dependencies are inferred from the claim text.