US 2014/0235455 A1 · USE OF HOXA9 GENE AS A BIOMARKER FOR THE DETECTION OF HEPATOCELLULAR CARCINOMA

Use of hoxa9 gene as a biomarker for the detection of hepatocellular carcinoma

AssigneesAcademia Sinica, Taipei Medical University

InventorsChing-Yu LIN, Jung-Chun LIN, Che-Chang CHANG, Yung-Kai HUANG, Guan Shuh BING, Hsiu-Wen HUANG, Ya-Wen LIN, Hung-Chung LAI, Yu-Lueng SHIH, Chung-Bao HSIEH, Chih-Chi KUO, Pei-Yu LIN, Ming-Song HSIEH, Chien-Jen CHEN

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Abstract

A method of detecting hepatocellular carcinoma includes the steps of: detecting a methylation level of a CpG site of HOXA9 gene in a biological sample taken from a suspected subject; and comparing the methylation level to a reference methylation level of a CpG site of HOXA9 gene in another biological sample taken from a normal subject not suffering from hepatocellular carcinoma, wherein when the methylation level is higher than the reference methylation level, the suspected subject is likely to suffer from hepatocellular carcinoma, and wherein each of the biological samples is selected from the group consisting of a blood sample, a serum sample, and a plasma sample.

Claims11

Dependent claims

A method of detecting hepatocellular carcinoma, comprising:

detecting a methylation level of a CpG site of HOXA9 gene in a biological sample taken from a suspected subject;
and
comparing the methylation level to a reference methylation level of a CpG site of HOXA9 gene in another biological sample taken from a normal subject not suffering from hepatocellular carcinoma;
wherein when the methylation level is higher than the reference methylation level, the suspected subject is likely to suffer from hepatocellular carcinoma;
and
wherein each of the biological samples is selected from a group consisting of a blood sample, a serum sample, and a plasma sample.

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Dependencies are inferred from the claim text.