Methods and compositions for mesenchymal stem cell proliferation
AssigneeUniversity of Rochester
InventorsMichael Hoffman, Danielle Benoit
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Abstract
Provided is a method for increasing proliferation of mesenchymal stem cells. The method entails contacting the cells with 6-bromoindirubin-3′-oxime (BIO). This results in robust proliferation and “sternness” in a dose-dependent fashion, as indicated by the gene expression of two stem cell genes: Sox2 and Nanog.
Claims11
A method for stimulating proliferation of mesenchymal stem cells comprising the contacting the cells with a composition comprising 6-bromoindirubin-3′-oxime (BIO) in an amount sufficient to stimulate proliferation which is greater than proliferation in the absence of BIO.
A population of cells comprising mesenchymal stem cells which have been exposed to BIO in vitro and which have been proliferated in culture for at least 3 days after removal of BIO.
Dependencies are inferred from the claim text.