Benzamide Compounds and Related Methods of Use

A compound selected from compounds of a formula

• wherein each of R1 and R2 is independently selected from phenyl, benzyl, heteroaryl, and heteroarylalkyl moieties;
• each of E1 and E2 is independently selected from CH and N, provided at least one of E1 and E2 is CH;
• A is a divalent moiety selected from carbonyl, amino, carboxamido (—C(O)NH—), imidocarbyl (—C(NH)—) and a tautomer thereof (—N═C(NH2)—) with X;
• X is a divalent moiety selected from methylene, carbonyl, amino, and aza-substituted ethylene (—NHCH2—) moieties;
• Y is a divalent moiety selected from oxy, amino, alkylene, and aza-substituted alkylene moieties;
• and Z is a divalent moiety selected from sulfonyl, sulfinyl, thio, oxy, amino, and methylene moieties, providing where A is carbonyl, Z is sulfonyl and R1 and R2 are selected from phenyl and substituted phenyl, X is not amino or methylamino and Y is not amino, alkylamino, allylamino or benzylamino, and wherein each of R1, R2, A, X, Y and Z is optionally substituted with 1-10 substituents independently selected from but not limited to halo, cyano, nitro, hydroxy, amino, alkyl, cycloalkyl, cycloheteroalkyl, aryl, arylalkyl, alkoxy, alkenyl, haloalkyl, aminoalkyl, hydroxyalkyl, alkylene, alkylsulfonyl, alkylsulfinyl, haloalkylsulfonyl, haloalkylsulfinyl, alkylamido, alkylsulfonamido, alkylthio, alkylcarbonyl, alkoxycarbonyl and combinations of such substituents;
• R3 is selected from said substituents and combinations thereof;
• and n is an integer from 0-4, and salts of said compounds.

A compound selected from compounds of a formula

• wherein R1 is selected from phenyl, benzyl, and heteroaryl moieties;
• X is a divalent moiety selected from amino, alkylamino, methylene, ethylene and a heteroatom-substituted ethylene moieties;
• R2 is selected from H, halo, C1-C6 alkyl and alkoxy moieties;
• and R3 is selected from N(R4)(R5) moieties where each of R4 and R5 is independently selected from H, alky and arylalkyl moieties and moieties where R4 and R5 together form alkylene or heteroatom-substituted alkylene moieties to provide an R3 moiety selected from
• and wherein R1 is optionally substituted with 1-10 substituents independently selected from but not limited to halogen, cyano, nitro, hydroxy, amino, alkyl, alkoxy, alkenyl, haloalkyl, aminoalkyl, hydroxyalkyl, alkylsulfonyl, alkylsulfinyl, haloalkylsulfonyl, haloalkylsulfinyl, alkylamido, alkylsulfonamido, alkylthio, alkylcarbonyl, alkoxycarbonyl and combinations of such substituents, providing where R3 is hexamethyleneimino, X is amino and R2 is H, R1 is not nitro- or bromosubstituted phenyl, and salts thereof.