Methods for the release of virus-like particles

A method for the release of baculovirus-expressed Virus-like Particles (VLP's) of non-enveloped viruses from insect cells, wherein the method comprises the step of mixing the insect cells with a salt, wherein the salt in water solution resulting from the mixing comprises at least 300 mOsmol/l of a salt of which the cation is selected from the group consisting of the alkali metals and the earth alkali metals, and of which the anion is selected from the group consisting of Cl−, Br−, and I−.