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US 2014/0234867 A1Published application
Antibodies Specific to Heterodimers of Bcl-2 Family and Uses Thereof
AssigneeEutropics Pharmaceuticals, Inc.
InventorsMichael H. Cardone, Anthony G. Letai
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Abstract
Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient.
Claims21
An isolated antibody specifically binding to a heterodimer of the Bcl-2 family.
A method for detecting the presence of a heterodimer of the Bcl-2 family in a tissue sample, comprising
- providing a tissue sample suspected of having a heterodimer of the Bcl-2 family,
- contacting an isolated antibody specifically binding to the heterodimer,
- detecting a signal that indicates binding of the antibody to the heterodimer, and
- determining the presence of the heterodimer in the biosample based on the intensity of the signal.
1 more element
A method for assessing whether a patient is sensitive or resistant to a drug that interferes with formation of a heterodimer of the Bcl-2 family, comprising:
- providing a tissue sample obtained from a patient,
- contacting the tissue sample with an isolated antibody specifically binding to a heterodimer of the Bcl-2 family,
- detecting a signal that indicates binding of the antibody to the heterodimer,
- determining the presence of the heterodimer based on the intensity of the signal, and
- assessing sensitivity or resistance of the patient to a drug that interferes with formation of the heterodimer based on the presence of the heterodimer.
2 more elements
Dependencies are inferred from the claim text.