Human keratinocytes ptch1 cell line
AssigneesGalderma Research & Development, Cnrs
InventorsElodie Burty, Thierry Magnaldo, Yannick Gache
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Abstract
A cellular model is described for targeting dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular mod& to screen for pharmacological compounds that can treat or prevent skin cancer and, in particular, Basal Cell Carinoma (BCC) lesions.
Claims14
An immortalized cell line of human keratinocytes with a natural exogene sequence bearing GLI binding sites in a reporter cassette which has an expression that is stable overtime,
The immortalized cell line ofclaim 3, wherein the cell line expresses other members of the pathway required for inhibition and activation of the pathway.
Dependencies are inferred from the claim text.