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US 2014/0234440 A1Published application
Method for isolating a chemotherapeutic agent resistant cancer cell with stem cell properties
AssigneeThe Rogosin Institute
InventorsLawrence GAZDA, Barry SMITH
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Abstract
The invention relates to the use of encapsulates of cancer cells, in agarose coated, agarose containing beads, for isolating chemotherapeutic resistant cells which have at least one stem cell property, such as expression of OCT4. The cells thus isolated are also a feature of the invention, as is a method for screening for potential therapeutic
Claims3
1-14. (canceled)
A method for determining prognosis of a subject suffering from cancer, comprising:
- (i) encapsulating a sample of cancer cells taken from said subject in an agarose containing, agarose coated bead;
- (ii) contacting said agarose containing, agarose containing bead with an anti-cancer agent known to be effective against said cancer cells, said anti-cancer agent being contacted to said bead at a concentration known to be effective, for a period of time known to be effective;
- (iii) determining number of cancer cells remaining in said bead after the period of time of (ii);
- and
- (iv) wherein a high number of said cancer cells as compared to a patient with a good prognosis is indicative of a poor prognosis for said subject.
2 more elements
Dependencies are inferred from the claim text.