Topical dermal delivery compositions using self assembling nanoparticles with cetylated components

A method for transdermal delivery of a bioactive agent, the method consisting of applying to the skin a delivery composition comprising:

• 1) An aqueous-dispersive phase consisting of water at 40% or more of the delivery composition by weight and supportive base components;
• 2) A dispersed hydrophobe phase containing nanoparticles, called cetosomes, derived of the following composition:
• a. 4-20% of delivery composition weight of four or more cetylated or stearyl esters in combinations best suited for the permeation of said active agent through the skin;
• said cetylated compounds are selected from the group consisting of cetyl arginine, cetyl betaine, cetyl 11-cyclohexylundecanoate, cetyl decanoate, cetyl dihomo-γ-linolenate, cetyl dimethicone, cetyl docosapentanoate, cetyl eicosapentanoate, cetyl ethylhexanoate, cetyl isolaurate, cetyl isononanoate, cetyl laurate, cetyl linolenate, cetyl methacrylate, cetyl 13-methyl myristate, cetyl myristoleate, cetyl myristate, cetyl oleate, cetyl ornithine, cetyl palmitate, cetyl palmitoleate, cetylated polyethylenimine, cetyl ricinoleate, cetyl stearate, cetyl stearidonate, stearyl glycyrrhentinate, stearyl stearate and stearyl methacrylate;
• and
• b. cetyl or stearyl alcohols, either singly or in combination, to have a molar ratio to cetyl esters of 1:3 or greater;
• and
• 3) A combination of interfacing agents derived of the following:
• a. 1-20% of delivery composition weight of one or more surfactants;
• and
• b. one or more polar solvents present in combined concentrations ranging from 2-30% of delivery composition weight, wherein the solvents are selected from the group consisting of alcohols, dipropylene glycol, ethoxydidlycol, glycerol, ethylene glycol, 1,2,6-hexane triol, 1,2,4-butane triol, propylene glycol ether of methyl glucose or a sorbitol, dimethicone copolyol, a polyethylene glycol, polyvinyl pyrrolidone and propylene glycol, wherein the active bioactive agent or combination of bioactive agents is incorporated in a suitable combination so as to provide effective transdermal delivery of the agent(s).