Method of Treating Skin Disorders using Nanoscale Delivery Devices and Transdermal Enhancing Compositions
OwnerOmathanu P. Perumal, Ranjith Kumar Averineniinventors
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Abstract
The present invention describes methods and compositions for treating diverse dermatological conditions, including acne and psoriasis, using zein containing nanocarrier devices for topical delivery of methotrexate, retinoic acid and benzoyl peroxide to select targets in the skin.
Claims36
A composition comprising a zein shell-core nanoparticle, zein-nanoemulsion or zein-nanomicelle containing a medicament, wherein said medicament is selected from retinoic acid, benzoyl peroxide (BPO) or methotrexate (MTX).
A method of treating a dermatological condition in a subject in need thereof comprising administering a cream or gel composition containing a zein shell-core nanoparticle, zein-nanoemulsion or zein-nanomicelle and a medicament selected from retinoic acid, benzoyl peroxide or methotrexate (MTX).
A formulation comprising a zein-nanoemulsion containing a phospholipid, a squalene or squalene monohydroperoxide (Sq-OOH), and a medicament selected from retinoic acid, benzoyl peroxide or methotrexate (MTX), wherein said zein-nanoemulsion exhibits a zeta-potential greater than about ±50.
A method of transdermally delivering methotrexate (MTX) to treat a condition in a subject in need thereof comprising administrating a composition comprising MTX in combination with two or more solvents selected from the group consisting of ethanol, transcutol, IPM, migloyl, phosphate buffer (4.0), santalol, eucalyptol, propylene glycol (PG), ethyl acetate, and combinations thereof.
A composition comprising methotrexate (MTX) in combination with two or more solvents selected from the group consisting of ethanol, transcutol, IPM, migloyl, phosphate buffer (4.0), santalol, eucalyptol, propylene glycol (PG), ethyl acetate, and combinations thereof.
Dependencies are inferred from the claim text.