Caged platinum nanoclusters for anticancer chemotherapeutics
AssigneeNational Health Research Institutes
InventorShu-Yi LIN
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Abstract
A caged platinum nanocluster complex is disclosed. The complex comprises (a) an amine-terminated dendrimer; and (b) a platinum nanocluster comprising platinum oxides, the platinum nanocluster being confined inside of the amine-terminated dendrimer. The complex exhibits cytotoxicity to cancer cells. A double-caged platinum nanocluster complex is also disclosed, which comprises polyethylene glycol (PEG) coated on the surface of a dendrimer caged platinum nanocluster complex. The double-caged caged platinum nanocluster complex comprises pH-sensitive bonds on the surface thereof. Also disclosed are methods of preparing and using the same.
Claims20
A double-caged platinum nanocluster complex, comprising:
- (a) a dendrimer;
- (b) a platinum nanocluster comprising platinum oxides, the platinum nanocluster being confined inside of the dendrimer;
- and
- (c) polyethylene glycol (PEG), coated on the surface of the amine-terminated dendrimer.
A caged platinum nanocluster complex, comprising:
- (a) an amine-terminated dendrimer;
- and
- (b) a platinum nanocluster comprising platinum oxides and having an average diameter of 0.93 nm with a standard deviation of 0.22 nm, the platinum nanocluster being confined inside of the amine-terminated dendrimer.
Dependencies are inferred from the claim text.