Loading patent…
AssigneeAPeT Holding B.V.
InventorsHendrik Jan Cornelis Meijerink, Lekhram Changoer, Willem Blom, Marinella Regina Visser, Henderik Willem Frijlink, Anko Cornelus Eissens
Estimating the term…
The present invention relates to compositions and methods for the prophylaxis or treatment of deficiencies in essential amino acid absorption and metabolism and/or of a pathology or symptom associated there with. In particular the invention concerns the treatment and/or prevention of ADHD, ADD and autism spectrum disorders. The present inventors have developed a method for prophylaxis or treatment of such symptoms and/or pathologies associated with a deficiency in essential amino acid absorption and/or metabolism, which method, stated generally, relies on the administration of nicotinamide, typically in a long-acting formulation so as to overcome the deficiencies of existing formulations, which have proven unsuitable for effective treatment.
1-17. (canceled)
A floating drug delivery system (FDDS), comprising a particle having a hollow, gas-filled core bordered by a wall of at least one polymer selected from the group of aqueous soluble, erodible, disintegrating and biodegradable polymers, the wall being surrounded by a coating comprising an active ingredient.
A floating drug delivery device comprising a capsule having a hollow, gas-filled core, bordered by a wall of at least one aqueous soluble, erodible, disintegrating or degradable polymer, the wall being surrounded by a coating comprising at least one active ingredient.
A method of treatment or prevention of a symptom or pathology associated with a deficiency in essential amino acid absorption and/or metabolism, the method comprising administering daily to a subject in need thereof ≦5 separate oral dosage units comprising nicotinamide in a total daily dosage of 10-500 mg/kg bodyweight of the subject.
A method of diagnosing a deficiency in essential amino acid absorption and/or metabolism in a subject, the method comprising determining the urinary excretion of one or more indoles from the subject.
Dependencies are inferred from the claim text.