Intravenous Infusion of Curcumin and a Calcium Channel Blocker
AssigneeSignpath Pharma, Inc.
InventorLawrence Helson
Life of this patent
Estimating the term…
Abstract
Compositions and methods for treating systemic diseases by intravenous administration of formulations of synthesized curcumin (diferuloylmethane) and concomitantly a calcium channel blocker to human subjects with neoplastic and neurodegenerative diseases are disclosed herein. The diseases are treated by prolonged administration of sub-optimal doses of liposomal curcumin or polymeric nanocurcumin or the sustained release curcumin from PLGA nanocurcumin at dosages below systemic hemolytic thresholds concomitantly with or without calcium channel blockers.
Claims22
A formulated pharmaceutical composition comprising
- a therapeutically effective amount of an intravenous formulation of curcumin enveloped by a polylactic glycolic acid (PLGA) copolymer and a layer of lipids to form a liposome.
A method comprising intravenous administration to a subject of a therapeutically effective amount of an intravenous composition of curcumin, wherein the synthesized curcumin is enveloped by a polylactic glycolic acid (PLGA) copolymer and a layer of lipids to form a liposome.
A method of treating a subject afflicted with one or more proliferative disorders comprising the steps of:
- identifying the subject in need of treatment against the one or more proliferative disorders;
- and
- administering a therapeutically effective amount of an intravenous formulation of curcumin enveloped by a polylactic glycolic acid (PLGA) copolymer and a layer of lipids to form a liposome sufficient to treat the proliferative disorder.
A method of treating one or more diseases or conditions in a subject comprising the steps of:
- identifying the subject in need of treatment against the disease or the condition;
- and
- administering a therapeutically effective amount of an intravenous formulation of curcumin enveloped by a polylactic glycolic acid (PLGA) copolymer and a layer of lipids to form a liposome.
A method of treating a tumor in a human subject comprising the step of:
- identifying the subject in need of the treatment against the tumor;
- and
- administering a therapeutically effective amount of an intravenous formulation of curcumin enveloped by a polylactic glycolic acid (PLGA) copolymer and a layer of lipids to form a liposome to treat the tumor.
A method of treating an ophthalmic tumor, an age related condition comprising macular degeneration and cataract or both in a subject comprising the step of:
- identifying the subject in need of treatment against the tumor or the age related condition;
- and
- administering a therapeutically effective amount of an intravenous formulation of curcumin enveloped by a polylactic glycolic acid (PLGA) copolymer and a layer of lipids to form a liposome for the treatment of the tumor or the age related condition.
Dependencies are inferred from the claim text.