Dissolution of Arterial Plaque
AssigneeAtheroNova Operations, Inc.
InventorsGiorgio Zadini, Filiberto Zadini
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Abstract
Some embodiments of the present invention provide pharmaceutical formulations, for treating atherosclerosis in a mammal, including a bile acid and/or a terpene atherosclerotic plaque emulsifier. Some embodiments provide methods for administering such pharmaceutical formulations. In some embodiments, pharmaceutical formulations include a combination of a bile acid and a terpene in amounts effective to result in plaque regression, and the amount of each individual emulsifier in the combination can be lower than an amount that is effective to result in plaque regression when the emulsifier is administered alone. In some embodiments, a statin can be administered simultaneously or sequentially with the pharmaceutical formulation.
Claims28
A pharmaceutical formulation, for treating atherosclerosis in a mammal consisting essentially of:
- a bile acid or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof in an amount effective to result in a serum concentration of greater than 50 μM in the mammal;
- and
- a terpene or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof in an amount effective to result in a serum concentration of about 1 μM to about 1M in the mammal;
- wherein the formulation is in an amount effective to result in regression of an atherosclerotic plaque in an artery of the mammal.
A method, of treating atherosclerosis in a mammal, comprising administering to a mammal a pharmaceutical formulation comprising:
- a bile acid or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof;
- and a terpene or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof;
- wherein the formulation is in an amount effective to result in regression of an atherosclerotic plaque in an artery of the mammal.
A pharmaceutical formulation, for treating atherosclerosis in a mammal, consisting essentially of:
- a bile acid or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof in an amount effective to result in a serum concentration of greater than 50 μM in the mammal;
- and
- a terpene or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof in an amount effective to result in a serum concentration of about 1 μM to about 1M in the mammal.
A method, of treating atherosclerosis in a mammal, comprising:
- administering to a mammal a pharmaceutical formulation comprising a terpene or a pharmaceutically acceptable salt, conjugate, hydrate, solvate, polymorph, or mixture thereof;
- wherein the formulation is in an amount effective to result in regression of an atherosclerotic plaque in an artery of the mammal.
Dependencies are inferred from the claim text.