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AssigneeMiMedx Group, Inc.
InventorsJohn Daniel, Randall Spencer, John Russo, Robert Tofe
Estimating the term…
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
1-34. (canceled)
A method for preparing a dehydrated tissue graft, comprising the steps:
A multilayered graft comprising two or more membranes layered over each other wherein said membranes are selected from the group consisting of washed and cleaned amnion, washed and cleaned chorion, allograft pericardium, allograft acelluar dermis, amniotic membrane, Wharton's jelly, purified xenograft Type-1 collagen, biocellulose polymers or copolymers, biocompatible synthetic polymer or copolymer films, purified small intestinal submucosa, bladder acellular matrix, cadaveric fascia, or any combination thereof wherein at least one of the layers is an amnion layer having substantially all of its epithelial layer removed while retaining its fibroblast layer.
Dependencies are inferred from the claim text.