Composition for management of periodontal disease
AssigneesKing Abdullah International Medical Research Center, National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences
InventorsNOHA MOHAMED ZAKI RAYAD, IBRAHIM MAGHRABI, MOHAMED MOSTAFA HAFEZ MAHMOUD
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Abstract
The composition for management of periodontal diseases includes a gel matrix having a polymer system and a plurality of microspheres dispersed in the polymer system. The polymer system contains about one-half a dose of medicament, while the microspheres contain the remainder. Upon administration of the composition into the periodontal cavity, the medicament in the polymer system provides an initial therapeutic benefit, while the remainder of the medication is released over time via degradation of the microspheres. This biphasic pattern of medicament delivery provides increased efficacy of the medicament through sustained delivery of the same.
Claims20
A delivery system for management of periodontal diseases, comprising:
- a polymer system forming a gel matrix adapted for carrying about one-half of a dose of a medicament for treating periodontal disease, the gel matrix having about 0.5-5% by weight of chitosan and providing rapid release of the medicament to achieve therapeutic levels;
- and
- a plurality of microspheres suspended and dispersed in the gel matrix, each one of the plurality of micro spheres having a particle size ranging from about 50-800 μm, the micro spheres containing the remainder of the dose, the microspheres providing gradual time release of the medicament to maintain the therapeutic levels of medicament for a sustained period of time, wherein
- said gel matrix comprises a polymer selected from the group consisting of chitosan and poloxamer members,
- said microspheres comprise a polymer selected from the group consisting of ethylcellulose, poly(lactide-co-glycolide) polymer, and polycaprolactone polymer, and
- said microspheres are constructed from biodegradable and biocompatible polymers.
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A composition for management of periodontal diseases, comprising:
- a polymer system forming a gel matrix, the gel matrix having about 0.5-5% by weight of chitosan;
- a plurality of microspheres suspended and dispersed in the gel matrix, each one of the plurality of microspheres having a particle size ranging from about 50-800 μm;
- an effective amount of an active ingredient for the management of periodontal disease, about one-half of the effective amount being dispersed in the gel matrix for rapid release of therapeutic levels of the active ingredient, the microspheres containing the remainder of the effective amount and providing gradual time release of the active ingredient to maintain the therapeutic levels of medicament for a sustained period of time, wherein
- said gel matrix comprises a polymer selected from the group consisting of chitosan and poloxamer members;
- and
- said microspheres comprise a polymer selected from the group consisting of ethylcellulose, poly(lactide-co-glycolide) polymer, and polvcaprolactone polymer, and
- said microspheres are constructed from biodegradable and biocompatible polymers.
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Dependencies are inferred from the claim text.