Plant viral vaccines and therapeutics
AssigneesViral Genetics, Inc., Scott & White Healthcare, The Texas A&M University System
InventorsMartha Karen Newell, Richard Tobin, Susannah K. Rogers
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Abstract
The invention relates to methods and related products for preventing and treating disease, based on the use of plant viral vaccines and plant viral defense strategies. The methods also involve the identification of appropriate therapeutic strategies for diseases such as cancers.
Claims25
A vaccine, comprising:
- an isolated plant viral antigen, wherein the plant viral antigen is immunogenic, and a pharmaceutically acceptable carrier.
A method for treating a subject, comprising:
- administering an anti-viral compound to the subject, wherein the subject has a disease associated with a plant virus, in an effective amount to reduce infection with the plant virus in the subject.
A method, comprising:
- determining whether a subject having a virally caused disease, such as cancer, has been exposed to a plant virus that causes the disease, and treating the subject with a compound that is a plant defense mechanism against the plant virus in an effective amount to reduce infection of the subject with the plant virus.
A method for silencing plant virus gene expression in a mammal needing relief from the gene expression, comprising:
- administering to the mammal an inhibitory nucleic acid that targets the genome of an essential plant virus in an effective amount to reduce infection of the mammal with the plant virus.
A composition comprising:
- a vector comprising a nucleic acid encoding an inhibitory nucleic acid that targets the genome of an essential plant virus operably linked to a mammalian promoter.
A method, comprising:
- performing a physical analytical step on a biological sample, optionally a fecal sample, of a subject,
- identifying the presence of plant virus in the biological sample based on the physical analytical step, and
- determining a course of treatment for the subject based on the presence of the plant virus, wherein the presence of the plant virus is indicative of a predisposition to cancer.
A method for treating a plant virus associated cancer, comprising:
- administering to a subject having a plant virus associated cancer an anti-viral compound in an effective amount to treat the cancer, wherein the anti-viral compound is a compound that interferes with viral synthesis.
A method for identifying an anti-cancer agent, comprising:
- performing a physical analytical step on a plant to determine a plant defense mechanism for preventing infection with a plant virus,
- identifying an association of the plant virus with a mammalian cancer, and
- selecting the plant defense mechanism as an anti-cancer agent for the mammalian cancer.
25-29. (canceled)
Dependencies are inferred from the claim text.