Cancer vaccines and vaccination methods
OwnerJames G. Bender, John S. Yuinventors
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Abstract
Compositions of multipeptide vaccines comprising at least seven tumor associated antigens, compositions of antigen presenting cell (e.g., dendritic cell) based vaccines presenting epitopes from at least seven tumor associated antigens, and methods of making same, are provided herein. Also, disclosed are methods for treating gynecological and peritoneal cancers using such vaccines.
Claims29
A composition comprising a mixture of at least one major histocompatibility complex (MHC) class I peptide epitope of at least seven antigens selected from the group consisting of mesothelin, NY-ESO-1, FBP, HER-2/neu, IL-13 receptor α2, MAGE-A1, EphA2, p53, k-Ras, Ep-CAM, MUC1, Survivin, hTERT, and WT1.
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A composition comprising isolated dendritic cells, wherein the dendritic cells present peptide sequences on their cell surface, wherein the peptide sequences comprise at least one MHC class I peptide epitope of at least seven of the following antigens:
- Mesothelin, NY-ESO-1, FBP, HER-2/neu, IL-13 receptor α2, MAGE-A1, EphA2, p53, k-Ras, Ep-CAM, MUC1, Survivin, hTERT, and WT1.
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Dependencies are inferred from the claim text.