Novel anti-cancer isocarbostyril alkaloid conjugates

A compound of Formula I:

• wherein
• R1 and R5, are independently, H, OH or O-(L)n-B;
• R2, R3 and R4, are independently, H or -(L)n-B;
• provided that one, two or three of R1, R2, R3, R4 and R5 comprise -(L)n-B;
• L is a linker group;
• B is a lipophilic biomolecule;
• n is 0 or 1;
• and
• is a single or a double bond,
• or a stereoisomer thereof, or a pharmaceutically acceptable salt and/or solvate.