Anti-cd40 antibodies and uses thereof
AssigneeBaylor Research Institute
InventorsJacques F. Banchereau, Gerard Zurawski, Sandra Zurawski, SangKon Oh
Life of this patent
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Abstract
The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.
Claims21
1-56. (canceled)
An antibody or an antigen binding fragment thereof that binds to CD40, wherein the antibody or an antigen binding fragment comprises light chain complementarity determining regions 1, 2 and 3 of the light chain variable region of SEQ ID NO:
- 4 or SEQ ID NO:
- 5 and heavy chain complementarity determining regions 1, 2 and 3 of the heavy chain variable region of SEQ ID NO:
- 3.
An isolated nucleic acid sequence encoding an antibody or an antigen binding fragment thereof that binds to CD40, wherein the antibody or antigen binding fragment thereof comprises light chain complementarity determining regions 1, 2 and 3 of the light chain variable region of SEQ ID NO:
- 4 or SEQ ID NO:
- 5 and heavy chain complementarily determining regions 1, 2 and 3 of the heavy chain variable region of SEQ ID NO:
- 3.
A method of making an antibody or antigen binding fragment thereof that binds to CD40, wherein the method comprises the expression by a host cell of an antibody or an antigen binding fragment that comprises light chain complementarity determining regions 1, 2 and 3 of the light chain variable region of SEQ ID NO:
- 4 or SEQ ID NO:
- 5 and heavy chain complementarity determining regions 1, 2 and 3 of the heavy chain variable region of SEQ ID NO:
- 3 fragment.
Dependencies are inferred from the claim text.