Method and reagent for diagnosis and/or evaulation of progression of graft-versus-host disease

A method of treating graft-versus-host disease (GVHD), comprising:

• (a) identifying a human subject treated with hematopoietic stem cell transplantation;
• (b) measuring the level of CCL8 protein in a first sample obtained from the human subject at a first time point and in a second sample obtained from the human subject at a second, later time point, or obtaining results of a measurement of CCL8 protein in the samples;
• and
• (c) initiating therapy for GVHD when the level of CCL8 protein in the second sample is increased.

A method of treating graft-versus-host disease (GVHD), comprising:

• (a) identifying a human subject treated with hematopoietic stem cell transplantation;
• (b) measuring the level of CCL8 protein in a sample obtained from the human subject and comparing the level of CCL8 protein with that in another sample or with those in other samples obtained later from the human subject, or obtaining the result of said comparison of the levels of CCL8 protein;
• and
• (c) initiating therapy for GVHD based on the result of said comparison of the levels of CCL8 protein.