Use of c-met protein for predicting the efficacy of anti-hepatocyte growth factor ("hgf") antibodies in esophageal and gastric cancer patients
AssigneeAmgen Inc.
InventorsAbraham Anderson, Kelly Oliner, Rui Tang, Elwyn Loh, Sarita Dubey
Life of this patent
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Abstract
The present invention relates to use of the human Met receptor (also known as “c-Met”) for predicting the efficacy of inhibitors of the HGF-Met pathway, and in particular, anti-HGF antibodies, in the treatment of esophageal and gastric cancer patients. The present invention also relates to methods and kits for predicting the usefulness of anti-HGF antibodies in the treatment of esophageal and gastric cancer.
Claims43
A method for predicting the efficacy of an anti-HGF antibody, comprising the step of determining a percentage of tumor cells having c-Met protein in a sample obtained from a patient diagnosed with gastric cancer, wherein a percentage of at least 1 percent of the tumor cells having c-Met predicts that administration of the anti-HGF antibody will treat the gastric cancer in the patient.
A method of predicting whether a patient suffering from gastric cancer will respond to treatment with an anti-HGF antibody, comprising the step of determining a percentage of tumor cells having c-Met protein in a sample obtained from a patient diagnosed with gastric cancer, wherein a percentage of at least 1 percent of tumor cells having c-Met protein predicts that administration of the anti-HGF antibody will treat the gastric cancer in the patient.
A method of screening for patients diagnosed with gastric cancer as being responsive to treatment with an anti-HGF antibody comprising the step of determining a percentage of tumor cells having c-Met protein present in a sample obtained from a patient diagnosed with gastric cancer, wherein a percentage of at least 1 percent of tumor cells having c-Met protein predicts that the patient with gastric cancer will be responsive to treatment with an anti-HGF antibody.
A method for predicting the efficacy of an anti-HGF antibody, comprising the step of determining the maximum staining intensity of c-Met protein in tumor cells obtained from a patient diagnosed with gastric cancer, wherein a maximum staining intensity of at least 1 predicts that administration of the anti-HGF antibody will treat the gastric cancer in the patient when administered.
A method of predicting whether a patient suffering from gastric cancer will respond to treatment with an anti-HGF antibody, comprising the step of determining the maximum staining intensity of c-Met protein in tumor cells obtained from a patient diagnosed with gastric cancer, wherein a maximum staining intensity of at least 1 predicts that administration of the anti-HGF antibody will treat the gastric cancer in the patient.
A method of screening for patients diagnosed with gastric cancer as being responsive to treatment with an anti-HGF antibody comprising the step of determining the maximum staining intensity of c-Met protein in tumor cells obtained from a patient diagnosed with gastric cancer, wherein a maximum staining intensity of at least 1 predicts that the patient with gastric cancer will be responsive to treatment with an anti-HGF antibody.
A method for predicting the efficacy of an anti-HGF antibody, comprising the step of determining the H-score for c-Met protein in tumor cells obtained from a patient diagnosed with gastric cancer, wherein an H-score of at least 1 predicts that administration of the anti-HGF antibody will treat the gastric cancer in the patient.
A method of predicting whether a patient suffering from gastric cancer will respond to treatment with an anti-HGF antibody, comprising the step of determining the H-score for c-Met protein in tumor cells obtained from a patient diagnosed with gastric cancer, wherein an H-score for c-Met protein of greater than 1 predicts that administration of the anti-HGF antibody will treat the gastric cancer in the patient.
A method of screening for patients diagnosed with gastric cancer as being responsive to treatment with an anti-HGF antibody comprising the step of determining the H-score of c-Met protein in tumor cells obtained from a patient diagnosed with gastric cancer, wherein an H-score for c-Met protein of at least 1 predicts that the patient with gastric cancer will be responsive to treatment with an anti-HGF antibody.
A method of treating a patient diagnosed with gastric cancer, wherein a sample of tumor cells obtained from the patient diagnosed with gastric cancer has a percentage of at least 1 percent of the tumor cells having c-Met protein present, as measured in an in vitro assay, the method comprising the step of administering to a patient diagnosed with gastric cancer an anti-HGF antibody effective to provide a therapeutic benefit.
A method of treating a patient diagnosed with gastric cancer, wherein a sample of tumor cells obtained from the patient diagnosed with gastric cancer has a maximum staining intensity of c-Met protein in tumor cells of at least 1, as measured in an in vitro assay, the method comprising the step of administering to a patient diagnosed with gastric cancer an anti-HGF antibody effective to provide a therapeutic benefit.
A method of treating a patient diagnosed with gastric cancer, wherein a sample of tumor cells obtained from the patient diagnosed with gastric cancer has an H-score for c-Met protein of at least 1, as measured in an in vitro assay, the method comprising the step of administering to a patient diagnosed with gastric cancer an anti-HGF antibody effective to provide a therapeutic benefit.
43-62. (canceled)
Dependencies are inferred from the claim text.