Adjuvant therapy for staphylococcal infection with enterotoxin specific mabs
AssigneeAlbert Einstein College of Medicine of Yeshiva University
InventorsBettina Fries, Avanish Varshney, Emily Cook, Xiaobo Wang
Life of this patent
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Abstract
Antibodies to SEB, fragments thereof, and compositions comprising such are provided. Therapies for staphylococcal infection are provided, as well as assays for identifying additional agents useful in such therapies. An isolated antibody, or an isolated antigen-binding fragment of an antibody, is provided which antibody or antigen-binding fragment binds to staphylococcal enterotoxin B (SEB) and which antibody or antigen-binding fragment comprises a heavy chain variable CDR3 comprising the sequence RIYYGNNGGVMDY (SEQ ID NO:30); ARTAGLLAPMDY (SEQ ID NO:31); ARDTMRKCYCELKLKPPAEHPGPA (SEQ ID NO:32) or VRDL YGDYVGRY A Y (SEQ ID NO:48).
Claims32
An isolated antibody, or an isolated antigen-binding fragment of an antibody, which antibody or antigen-binding fragment binds to staphylococcal enterotoxin B (SEB) and which antibody or antigen-binding fragment comprises a heavy chain variable CDR3 comprising the sequence RIYYGNNGGVMDY (SEQ ID NO:30);
- ARTAGLLAPMDY (SEQ ID NO:31);
- ARDTMRKCYCELKLKPPAEHPGPA (SEQ ID NO:32) or VRDLYGDYVGRYAY (SEQ ID NO:48).
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An isolated antibody, or the isolated antigen-binding fragment of an antibody, which antibody or antigen-binding fragment binds to staphylococcal enterotoxin B (SEB) comprising SEQ ID NO:1 and which antibody or antigen-binding fragment comprises an amino acid sequence comprising three CDRs, each one of which has at least 90% identity to a different heavy chain variable CDR selected from CDR1, CDR2 and CDR3 as set forth in SEQ ID NO:36, 39, and 30, or from CDR1, CDR2 and CDR3 as set forth in SEQ ID NO:37, 40, and 31, or from CDR1, CDR2 and CDR3 as set forth in SEQ ID NO:49, 50, and 48.
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Dependencies are inferred from the claim text.