Treatment of neurological conditions
AssigneeCSL Limited
InventorsBrent Steven McKenzie, Peter Frederick CURWEN, Eugene MARASKOVSKY
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Abstract
The present invention is directed to a method for treating an inflammatory neurodegenerative condition of the CNS in a subject comprising administering to said subject a G-CSF or G-CSFR inhibiting agent selected from the group consisting of an antibody specific for G-CSF, a soluble G-CSFR or a G-CSF-binding portion thereof and a 20 to 30 nucleotide sense or antisense molecule targeted to a nucleic acid molecule encoding G-CSF.
Claims8
A method for treating an inflammatory neurodegenerative condition of the CNS in a subject, said method comprising administering to said subject a G-CSF or G-CSFR inhibiting agent selected from the group consisting of an antibody specific for G-CSF;
- a soluble G-CSFR or a G-CSF-binding portion thereof;
- and a 20 to 30 nucleotide sense or antisense molecule targeted to a nucleic acid molecule encoding G-CSF, said nucleic acid molecule comprising the sequence set forth in SEQ ID NO:3;
- or 20 to 30 nucleotide sense or antisense molecule targeted to a nucleic acid molecule encoding a G-CSFR, said nucleic acid molecule comprising the sequence set forth in SEQ ID NO:7.
Dependencies are inferred from the claim text.