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US 2014/0234301 A1Published application
Modulation of PILR to Treat Immune Disorders
AssigneeMerck Sharp & Dohme Corp.
InventorsCristina M. Tato, Barbara Joyce-Shaikh, Daniel J. Cua
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Abstract
The present invention provides methods of using PILRα agonists, or PILRβ antagonists, to treat immune disorders, such as autoimmune and inflammatory disorders, including CNS, joint and gut inflammation.
Claims13
A method of treating an immune disorder comprising administering to a subject in need of such treatment an effective amount of an antagonist of PILRβ (SEQ ID NO:
- 4).
2-3. (canceled)
The method of claim 2 wherein the antagonist of PILRβ comprises a soluble polypeptide fragment of PILRβ (SEQ ID NO:
- 4).
8-13. (canceled)
19-21. (canceled)
Dependencies are inferred from the claim text.