Therapies for chronic renal failure using one or more integrin antagonists
AssigneesImperial College of Science, Technology and Medicine, Biogen Idec MA Inc.
InventorsRoy Lobb, Charles Pusey, Andrew Allen
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Abstract
The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certain integrin antagonists.
Claims17
A method of treatment for a mammal in, or at risk of, chronic renal failure comprising administering to said mammal a therapeutically effective amount of an integrin antagonist.
A method of treatment for a mammal in, or at risk of, chronic renal failure comprising administering to said mammal a therapeutically effective amount of two or more integrin antagonists, wherein at least two of the antagonists include a first integrin antagonist that antagonizes the interaction between an alpha4-containing subunit and its cognate ligand or receptor, and a second integrin antagonist that antagonizes the interaction between another alpha-containing subunit that is not alpha4.
Dependencies are inferred from the claim text.