Isoflavonoid compounds and methods for the treatment of cancer
AssigneeMarshall Edwards, Inc.
InventorsGeorge Jeoffreys, Alison Johnson, Andrew Heaton, Ofir Moreno
Life of this patent
Estimating the term…
Abstract
Provided herein is a pharmaceutical composition comprising at least one isoflavonoid. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions.
Claims17
A pharmaceutical composition comprising a compound of formula II or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is hydroxy, alkoxy, haloalkyl, or halo;
- R2 is hydroxy or alkoxy;
- R3 is alkyl, halo, or haloalkyl;
- R4, R5, and R6 are independently hydrogen, hydroxy, alkoxy, halo, haloalkyl, or alkyl;
- and
- R7 is alkyl or hydrogen.
A pharmaceutical composition comprising a compound of formula IV or a pharmaceutically acceptable salt thereof:
- wherein
- R8 is hydrogen.
(canceled)
A kit comprising a composition comprising a compound of formula II or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is hydroxy, alkoxy, haloalkyl, or halo;
- R2 is hydroxy or alkoxy;
- R3 is alkyl, halo, or haloalkyl;
- R4, R5 and R6 are independently hydrogen, hydroxy, alkoxy, halo, haloalkyl, or alkyl;
- and
- R7 is alkyl or hydrogen;
- or
- a compound of formula IV or a pharmaceutically acceptable salt thereof:
- wherein
- R8 is hydrogen;
- and
- a sealable, plastic infusion bag.
(canceled)
A method of treating cancer in an individual in need of cancer therapy, the method comprising administering to the individual a composition comprising a compound of formula II or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is hydroxy, alkoxy, haloalkyl, or halo;
- R2 is hydroxy or alkoxy;
- R3 is alkyl, halo, or haloalkyl;
- R4, R5 and R6 are independently hydrogen, hydroxy, alkoxy, halo, haloalkyl, or alkyl;
- and
- R7 is alkyl or hydrogen;
- or
- a compound of formula IV or a pharmaceutically acceptable salt thereof:
- wherein
- R8 is hydrogen.
Dependencies are inferred from the claim text.