Fibroblast Growth Factor Receptor-Derived Peptides Binding to NCAM
AssigneeKobenhavns Universitet
InventorsVladimir Berezin, Elisabeth Bock, Artur Kochoyan
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Abstract
The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.
Claims21
-35. (canceled)
A method for modulating NCAM signaling comprising administering to a subject in need thereof an isolated peptide of 5 to 25 contiguous amino acids, said peptide comprising an amino acid sequence derived from FGFR Ig2 and selected from the group consisting of:
- (SEQ ID NO:
- 1)
- TSPEKMEKKL
- (SEQ ID NO:
- 2)
- AKTVKFK
- (SEQ ID NO:
- 3)
- RWLKNGKEFK
- (SEQ ID NO:
- 4)
- TWSIIMDSV
- (SEQ ID NO:
- 5)
- SDKGNYTCIVEN
- and
- (SEQ ID NO:
- 6)
- TYQLDVVERS,
- or a fragment or variant thereof, said variant being at least 70% identical to said amino acid sequence, and said fragment having a length of 5 or more amino acid residues, wherein said peptide specifically binds to NCAM.
A method for modulating NCAM signaling comprising administering to a subject in need thereof an isolated peptide consisting of an amino acid sequence derived from FGFR Ig2 and selected from the group consisting of:
- (SEQ ID NO:
- 1)
- TSPEKMEKKL
- (SEQ ID NO:
- 2)
- AKTVKFK
- (SEQ ID NO:
- 3)
- RWLKNGKEFK
- (SEQ ID NO:
- 4)
- TWSIIMDSV
- (SEQ ID NO:
- 5)
- SDKGNYTCIVEN
- and
- (SEQ ID NO:
- 6)
- TYQLDVVERS
- or a fragment or variant thereof, said variant being at least 70% identical to said amino acid sequence, and said fragment having a length of 5 or more amino acid residues, wherein said peptide specifically binds to NCAM.
Dependencies are inferred from the claim text.