Therapeutics Using Adipose Cells and Cell Secretions
AssigneeCell Ideas Pty Ltd.
InventorsGraham Vesey, Rebecca Anne Webster, Richard Lilischkis
Life of this patent
Estimating the term…
Abstract
The invention relates to compositions comprising (i) adipose tissue-derived cell secretions or (ii) an adipose tissue-derived cell suspension, optionally comprising adipocytes, or (iii) a combination of adipose tissue-derived cell secretions and an adipose tissue-derived cell suspension, optionally comprising adipocytes, and to their use in pharmaceutical compositions and methods for treatment of various conditions. The invention also relates to improved methods, agents and compositions for cryopreservation of cells.
Claims59
A composition comprising adipose tissue-derived cells and adipose tissue-derived cell secretions.
A method for the cryopreservation of a cell, the method comprising combining said cell with a composition comprising cell secretions and storing said combination in a frozen state.
A method of alleviating pain in a mammalian subject, the method comprising administering to the subject a pharmaceutical composition which comprises (i) adipose tissue-derived cell secretions, or (ii) an adipose tissue-derived cell suspension, or (iii) a combination of (i) and (ii), wherein said administration to said subject is by intramuscular injection or by subcutaneous injection or topical administration.
A method of alleviating back pain in a mammalian subject, the method comprising administering to the subject a pharmaceutical composition which comprises (i) adipose tissue-derived cell secretions, or (ii) an adipose tissue-derived cell suspension, or (iii) a combination of (i) and (ii), wherein said administration to said subject is by intramuscular injection or by subcutaneous injection or topical administration.
A method of alleviating neuropathic pain in a mammalian subject, the method comprising administering to the subject a pharmaceutical composition which comprises (i) adipose tissue-derived cell secretions, or (ii) an adipose tissue-derived cell suspension, or (iii) a combination of (i) and (ii).
A method of treating a condition selected from the group consisting of an inflammatory disorder, a ligament injury and a tendon injury, or alleviating pain associated with an inflammatory disorder, a ligament injury or a tendon injury, in a mammalian subject, comprising administering to the subject a pharmaceutical composition which comprises (i) adipose tissue-derived cell secretions, or (ii) an adipose tissue-derived cell suspension, or (iii) a combination of (i) and (ii), wherein said administration to said subject is at a site remote from the site of said condition.
A method of treating a joint disease or condition in a subject, the method comprising administering to the subject a pharmaceutical composition which comprises (i) adipose tissue-derived cell secretions, or (ii) an adipose tissue-derived cell suspension, or (iii) a combination of (i) and (ii), wherein said administration to said subject is at a site remote from the site of said condition.
Use of (i) adipose tissue-derived cell secretions, or (ii) an adipose tissue-derived cell suspension, or (iii) a combination of (i) and (ii), for the preparation of a pharmaceutical composition for alleviating pain in a mammalian subject.
Use of (i) adipose tissue-derived cell secretions, or (ii) an adipose tissue-derived cell suspension, or (iii) a combination of (i) and (ii), for the preparation of a pharmaceutical composition for use in the treatment of a condition selected from the group consisting of an inflammatory disorder, a ligament injury and a tendon injury, or alleviating pain associated with an inflammatory disorder, a ligament injury or a tendon injury, in a mammalian subject, wherein the composition is suitable for administration to a site of said subject remote from the site of said condition.
Use of (i) adipose tissue-derived cell secretions, or (ii) an adipose tissue-derived cell suspension, or (iii) a combination of (i) and (ii), for the preparation of a pharmaceutical composition for use in the treatment of a joint disease or condition in a mammalian subject, wherein the composition is suitable for administration to a site of said subject remote from the site of said condition.
A kit comprising (a) a pharmaceutical composition selected from the group consisting of (i) a composition comprising adipose tissue-derived secretions, (ii) a composition comprising an adipose tissue-derived cell suspension, and (iii) a combination of (i) and (ii);
- and (b) instructions for use of said kit in alleviating pain in a mammalian subject.
A kit comprising (a) a pharmaceutical composition selected from the group consisting of (i) a composition comprising adipose tissue-derived secretions, (ii) a composition comprising an adipose tissue-derived cell suspension, and (iii) a combination of (i) and (ii);
- and (b) instructions for use of said kit in treatment of a condition selected from the group consisting of an inflammatory disorder, a ligament injury and a tendon injury, or alleviating pain associated with an inflammatory disorder, a ligament injury or a tendon injury, wherein said treatment comprises administration of said pharmaceutical composition to a site on a subject remote from the site afflicted by the condition.
A kit comprising (a) a pharmaceutical composition selected from the group consisting of (i) a composition comprising adipose tissue-derived secretions, (ii) a composition comprising an adipose tissue-derived cell suspension, and (iii) a combination of (i) and (ii);
- and (b) instructions for use of said kit in treatment of a joint disease or condition in a mammalian subject, wherein said treatment comprises administration of said pharmaceutical composition to a site on a subject remote from the joint afflicted by the joint disease or condition.
Dependencies are inferred from the claim text.