Heteroaromatic compounds as pi3 kinase modulators and methods of use

A compound having Formula (I):

• or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically salt or a prodrug thereof, wherein:
• each of W1, W2 and W3 is independently N or CRc;
• Z is D, CN, N3, or
• X is H, D, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)heterocyclyl, —(C1-C4)alkylene-(C3-C6)cycloalkyl, —(C1-C4)alkylene-(C3-C6)heterocyclyl, (C6-C10)aryl, or 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, wherein each of the (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)heterocyclyl, —(C1-C4)alkylene-(C3-C6)cycloalkyl, —(C1-C4)alkylene-(C3-C6)heterocyclyl, (C6-C10)aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, N3, ORa, SRa, NRaRb, —C(═O)NRaRb, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —(C1-C4)alkylene-CN, —(C1-C4)alkylene-ORa, —(C1-C4)alkylene-NRaRb, (C6-C10)aryl, and 5-10 membered heteroaryl;
• Y is (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)heterocyclyl, —(C1-C4)alkylene-(C3-C6)cycloalkyl, —(C1-C4)alkylene-(C3-C6)heterocyclyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, or 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, wherein each of the (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)heterocyclyl, —(C1-C4)alkylene-(C3-C6)cycloalkyl, —(C1-C4)alkylene-(C3-C6)heterocyclyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, N3, ORa, SRa, NRaRb, —C(═O)NRaRb, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, —(C1-C4)alkylene-CN, —(C1-C4)alkylene-ORa, —(C1-C4)alkylene-NRaRb, (C6-C10)aryl, and 5-10 membered heteroaryl;
• R1 is H, D, Cl, ORa, NRaRb, (C1-C6)aliphatic, or (C3-C6)cycloalkyl, wherein each of the (C1-C6)aliphatic and (C3-C6)cycloalkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N3, ORa, SRa, and NRaRb;
• each Ra and Rb is independently H, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)heterocyclyl, (C6-C10)aryl, 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, —(C1-C4)alkylene-(C6-C10)aryl, —(C1-C4)alkylene-(5-10 membered heteroaryl), or Ra and Rb are taken together with the nitrogen atom to which they are attached form a 3-8 membered heterocyclic ring, wherein each of the above substituents is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N3, OH, NH2, (C1-C6)alkoxy, and (C1-C6)alkylamino;
• and
• each Rc is independently H, D, F, Cl, Br, I, N3, CN, OH, NH2, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylamino, (C3-C6)cycloalkyl, (C3-C6)heterocyclyl, (C6-C10)aryl, or 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, wherein each of the (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylamino, (C3-C6)cycloalkyl, (C3-C6)heterocyclyl, (C6-C10)aryl and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N3, OH, NH2, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, and (C1-C6)alkylamino.