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US 2014/0231697 A1Published application
Particles
AssigneeLife Technologies Corporation
InventorsEllen WENG, Geir FONNUM, Grete MODAHL, Astrid MOLTEBERG, Erling FINNE, Torkel STENE
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Abstract
A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.
Claims26
1-31. (canceled)
A composition comprising a non-autofluorescent coated magnetic polymer particle comprising:
- a porous matrix polymer particle comprising superparamagnetic crystals on the surface and in the pores thereof, wherein majority of the superparamagnetic crystals are within pores of the porous matrix polymer particle, and wherein the porous matrix polymer particle is essentially free of conjugated delocalised electron systems other than those found in benzene rings;
- and
- a coat of a coating polymer wherein the coating polymer is formed by the polymerization of coating monomers wherein the coating monomers are essentially free of conjugated delocalised electron systems other than those found in benzene rings, wherein the coated magnetic polymer particle is essentially non-autofluorescent,
- wherein the coated magnetic polymer particle has a coefficient of variation (CV) of less than 10%, and
- wherein the coated magnetic polymer particle has a level of autofluorescence corresponding to a difference in the Mean Grey Value (ΔMGV) at an excitation wavelength of 450±25 nm for an exposure time of 500 ms or 600 ms of less than 600.
2 more elements
A non-autofluorescent uncoated magnetic polymer particle comprising:
- porous matrix polymer particles substantially free from conjugated delocalized electron systems other than benzene rings;
- and
- superparamagnetic polymer particles in the pores of the porous matrix polymer particles.
Dependencies are inferred from the claim text.