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US 2014/0231331 A1Published application
Method and apparatus for the filtration of biological solutions
AssigneeSpf Innovations, LLC
InventorsGaston de los Reyes, Leon Mir
Life of this patent
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Abstract
A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.
Claims22
A filtration module comprising:
- a sealant forming shell;
- a feed spacer disposed within the sealant forming shell;
- a membrane disposed adjacent the feed spacer;
- wherein the sealant forming shell, the feed spacer and the membrane partially form a feed compartment disposed within the sealant forming shell;
- a plurality of ribs disposed adjacent to the feed spacer and adjacent to the membrane, forming at least one channel having a zigzag topology;
- and
- wherein the sealant forming shell fluidly seals the feed compartment.
4 more elements
A filter module for filtering a fluid mixture comprising:
- a housing;
- a membrane disposed within the housing having a first surface;
- a feed spacer disposed adjacent the first surface of the membrane;
- and
- wherein the feed spacer and the membrane form at least one channel, the at least one channel disposed to establish a tangential flow of the fluid mixture over the first surface of the membrane and the at least one channel having a membrane area, a void volume, a length and a specific membrane area expressed as a ratio of the membrane area to the void volume and a dimensionless length expressed as a product of a channel length and the specific membrane area;
- and
- wherein the specific membrane area of the at least one channel is greater than about 40 cm−1, the dimensionless length of the at least one channel is greater than about 3,000, and the at least one channel having a width generally decreasing in a direction of the tangential flow.
4 more elements
Dependencies are inferred from the claim text.