Liquid to Liquid Biological Particle Fractionation and Concentration
AssigneeInnovaPrep LLC
InventorsZachary Allen Packingham, Andrew Edward Page, David Scott Alburty, Steven Dale Graham, Alec Douglas Adolphson
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Abstract
The present disclosure provides for devices, systems and methods for fractionation and concentration of particles from a fluid sample. This includes a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample; and a permeate pressure source in fluid communication with the cartridge; wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.
Claims17
A device for fractionation and concentration of particles from a fluid sample, the device comprising:
- a cartridge containing staged filters having porous surface in series of decreasing pore size for capture of particles from a fluid sample;
- and
- a permeate pressure source in fluid communication with the cartridge;
- wherein the particles are eluted from the porous surfaces and dispensed in a reduced fluid volume.
A system for fractionation and concentration of particles from a fluid sample, the system comprising:
- a reservoir holding a fluid sample;
- a fractionation and concentration cartridge including two or more staged filters;
- a permeate pressure device in fluid communication with the cartridge;
- a concentrating unit including an actuating integral valving to move sample through the cartridge;
- and
- a fluid dispenser source for collecting concentrated samples from the cartridge staged filters;
- wherein the fluid sample is moved through the concentrating unit, then the concentrated samples are eluted from the filters and dispensed.
A method for rapid fractionation and concentration of particles from a fluid sample, the method comprising:
- introducing a sample into the sample reservoir;
- initiating a fractionation and concentration cycle;
- passing the fluid sample through a series of filters;
- eluting a plurality of particles of decreasing particle size from each filter stage;
- and
- extracting a concentrated sample from each filter stage.
Dependencies are inferred from the claim text.