Turbulent flow mixing device for use in a chromatography system

A chromatography system comprising:

• a first pump for pumping a first flow stream comprising first fluid;
• a second pump for pumping a second flow stream comprising a second fluid, the second pump in parallel with the first pump;
• a turbulent flow mixing device located after the first and second flow streams are combined, the mixing device configured to create a turbulent flow condition to mix at least the first flow stream and the second flow stream and to provide flow through the mixing device during operation of the chromatography system;
• a column located downstream of the cartridge;
• and
• a detector located downstream of the column.

A method for enhancing peak signal in HPLC or SFC, the method comprising:

• pumping a first flow stream comprising a first fluid;
• pumping a second flow stream comprising second fluid;
• injecting a sample into the second flow stream;
• turbulating the first flow stream and second flow stream with injected sample in a cartridge;
• flowing the turbulated flow stream through a chromatography column;
• and
• detecting at least a portion of the sample.