Distributed randomization and supply management in clinical trials

A system to dispense medication in a multi-arm clinical trial, the system comprising:

• a computing device;
• and
• a machine-readable medium comprising instructions that, when executed by the computing device, cause the computing device to perform operations comprising:
• receiving a subject identifier and a trial identifier from an electronic data capture system, the trial identifier indicating the multi-arm clinical trial, the subject identifier indicating a subject enrolled in the multi-arm clinical trial;
• retrieving an arm identifier from a database based on the received subject identifier, the arm identifier indicating an arm in the multi-arm clinical trial to which the subject is assigned;
• and
• determining treatment for the arm identifier based on a treatment design previously configured for the multi-arm clinical trial, the treatment including a set of one or more units of at least one article type.

A machine-readable storage medium comprising operational instructions that, when executed by a processor, cause the processor to perform operations comprising:

• receiving a subject identifier and a trial identifier from an electronic data capture system, the trial identifier indicating a multi-arm clinical trial, the subject identifier indicating a subject enrolled in the multi-arm clinical trial;
• retrieving an arm identifier from a database based on the received subject identifier, the arm identifier indicating an arm in the multi-arm clinical trial to which the subject is assigned;
• and
• determining treatment for the arm identifier based on a treatment design previously configured for the multi-arm clinical trial, the treatment including a set of one or more units of at least one article type.