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US 2014/0228932 A1Published application
Methods of treatment directed to neointimal proliferation generated by endothelial shear stress patterns from drug-eluting bioresorbable vascular scaffold implantation
AssigneeAbbott Cardiovascular Systems Inc.
InventorRICHARD RAPOZA
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Abstract
Treatments of coronary heart disease including the effect of endothelial shear stress (ESS) on neointimal formation following a bioresorbable vascular scaffold implantation are disclosed.
Claims9
A method of treating vascular disease in a patient comprising:
- deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a segment of an artery of a patient, the polymer scaffold expanding during deployment which expands the segment to a target diameter such that struts of the scaffold are apposed on a wall of the segment,
- wherein immediately upon deployment the struts disrupt flow of blood through the segment resulting in recirculation zones upstream and downstream of the struts that are in gaps between struts,
- wherein the recirculation zones are exposed to a low shear stress from the blood flow less than 1 Pa for at least 60% of a surface of the struts and abluminal surfaces of the struts are exposed to a higher shear stress of at least 2 Pa, and
- wherein at least one year after deployment neointimal formation is higher in the recirculation zones than on the abluminal surfaces of the struts.
1 more element
A method of treating vascular disease in a patient comprising:
- expanding a bioabsorbable polymer in a segment of an artery of a patient such that the scaffold is expanded against a wall of the segment,
- wherein the scaffold comprises a coating including a polymer and a drug and the drug elutes from the coating into the artery,
- wherein flow of blood past the scaffold through the segment results in regions of low shear stress and regions of high shear stress immediately after the expanding,
- wherein after at least 80% of the drug elutes from the coating the regions of low shear stress promote neointimal proliferation resulting in a negative correlation between shear stress immediately after the expanding and the neointimal proliferation at least one year after the expanding.
1 more element
A method of treating vascular disease in a patient comprising:
- deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a segment of an artery of a patient, the polymer scaffold expanding during deployment which expands the segment to a target diameter such that some of the struts of the scaffold are in contact with a wall of the segment,
- wherein immediately after deployment at least some of the struts are malapposed such that an abluminal surface of the malapposed struts is not in contact with the wall of the segment,
- wherein immediately upon deployment the malapposed struts disrupt flow of blood through the segment resulting in recirculation zones upstream and downstream of the struts that are in gaps between the malapposed struts,
- wherein the recirculation zones are exposed to a low shear stress from the blood flow less than 1 Pa for at least 60% of a surface of the malapposed struts and abluminal surfaces of the struts are exposed to a higher shear stress of at least 2 Pa, and
- wherein at least one year after deployment neointimal formation is higher in the recirculation zones than on the abluminal surfaces of the struts.
2 more elements
Dependencies are inferred from the claim text.