Control of cardiac excitability using high frequency signals
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsLaurent Giovangrandi, Burak Dura, Michael Q. Chen, Omer T. Inan, Paul J. Wang
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Abstract
Certain embodiments of the present disclosure are directed toward devices, methods and systems for controlling depolarization in cardiac cells. One such device includes one or more circuits that are configured and arranged to generate an electrical stimulus at a high frequency. The circuit is configured to provide electrical stimulus over a period of time sufficient to depolarize the cardiac cells. An electrode arrangement is configured and arranged to deliver the high frequency electrical stimulus to cardiac cells and depolarize the cardiac cells.
Claims24
A device for controlling depolarization in cardiac cells, the device comprising:
- one or more circuits configured and arranged to
- generate an electrical stimulus at a frequency exceeding 1 kHz and less than 500 kHz;
- and
- maintain the electrical stimulus over a period of time sufficient to inhibit action potentials in the cardiac cells;
- and
- an electrode arrangement configured and arranged to
- deliver the electrical stimulus to cardiac cells and depolarize the cardiac cells.
A method for inhibiting excitability of cardiac cells comprising:
- generating a high frequency electrical stimulus at a frequency exceeding 1 kHz and less than 500 kHz;
- delivering the high frequency electrical stimulus to the cardiac cells;
- and
- maintaining the high frequency electrical stimulus to the cardiac cells over a period of time sufficient to inhibit action potentials in the cardiac cells.
A method for modeling cardiac re-entrant arrhythmia, the method comprising:
- generating a propagating depolarization wave in cardiac tissue by providing an electrical stimulus at a first location in the cardiac tissue;
- and
- directing the propagation of the depolarization wave back to the first location by inhibiting depolarization of cardiac tissue using high frequency electrical stimulus applied to portions of the cardiac tissue and thereby creating a re-entry arrhythmia.
A method for inducing depolarization of cardiac cells, the method comprising:
- generating a high frequency electrical stimulus at a frequency exceeding 1 kHz and less than 500 kHz;
- delivering the high frequency electrical stimulus to the cardiac cells;
- receiving an electrical signal from an electrode;
- filtering high frequency components from the electrical signal received from the cardiac cells;
- detecting a depolarization event using the filtered electrical signal;
- and
- stopping, in response to detecting the depolarization event, the delivery of the high frequency electrical stimulus to the cardiac cells.
Dependencies are inferred from the claim text.