Method of producing substances with supersaturated gas, transdermal delivery thereof, and uses thereof
AssigneeInvisiderm, LLC
InventorNorbert Kiss
Life of this patent
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Abstract
The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.
Claims21
1-15. (canceled)
A transdermal delivery device comprising:
- a) a housing including
- i) an external body shell comprising a fluid chamber assembly access cover detachably engaged with the external body shell;
- ii) an interior compartment including an open-ended delivery outlet and a vapor producing assembly compartment;
- and
- iii) a cartridge retaining container comprising an external covering shell and an internal cartridge compartment configured to hold a compressed gas cartridge, wherein the cartridge retaining container is detachably engaged with the external body shell;
- wherein the vapor producing assembly compartment is located between the open-ended delivery outlet and the cartridge retaining container;
- and
- b) a vapor producing assembly including
- i) a fluid chamber assembly comprising a fluid container and a removable fluid container cap;
- and
- ii) a pressure-temperature regulator assembly comprising at least two pressure regulators connected via an adaptor, wherein the pressure-temperature regulator assembly is set to reduce the pressure and increase the temperature of a compressed gas from the compressed gas cartridge;
- wherein the vapor producing assembly is substantially contained within the vapor producing assembly compartment.
A method of transdermally administering a therapeutically effective amount of dissolved molecular carbon dioxide comprising the step of administering a composition comprising a vapor including a supersaturated amount of dissolved molecular carbon dioxide to an individual using a transdermal delivery device according to claim 1.
A method of transdermally administering a therapeutically effective amount of a therapeutic agent comprising the step of administering a composition comprising a vapor including a supersaturated amount of dissolved molecular carbon dioxide and a therapeutic agent to an individual using a transdermal delivery device according to claim 1.
A method of producing a substance comprising a supersaturated amount of dissolved gas, the method comprising the steps of:
- a) placing the substance in an air-tight container;
- and
- b) exposing the substance to carbon dioxide, wherein upon exposure, the carbon dioxide dissolves into the substance in an amount greater than the substance could dissolve at 25° C. and 1 atm.
Dependencies are inferred from the claim text.