Method and Apparatus for Delivering a Substance

A device comprising:

• a housing configured to be delivered into a gastrointestinal (GI) tract of a biological body;
• at least one ultrasound transducer, disposed within the housing, configured to emit ultrasonic waves, external from the housing, within a frequency range of from about 20 kHz to about 10 MHz to a medium within or of the GI tract;
• circuitry, disposed within the housing, configured to drive the transducer;
• and
• a power source, disposed within the housing, configured to power the transducer and the circuitry.

A method of treating inflammatory bowel disease, the method comprising:

• providing a self-powered ultrasound device comprising at least one reservoir, each reservoir comprising a substance that includes a therapeutic molecule for treatment of inflammatory bowel disease;
• releasing the substance from the at least one reservoir into the gastrointestinal tract in the vicinity of target tissue for localized delivery of the substance;
• and
• emitting ultrasonic waves in a frequency range of from about 20 kHz to about 10 MHz with the ultrasound device to increase passage of the substance through a surface of the target tissue.