Method for producing 3,4-dihydroisoquinoline derivatives and production intermediates of same
AssigneeMitsui Chemicals Agro, Inc.
InventorsHideki Umetani, Nobuhiro Kondo, Fumie Kajino, Munetsugu Morimoto
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Abstract
Provided are an efficient method for producing 3,4-dihydroisoquinoline derivatives and useful production intermediates thereof. Provided is a method for producing 3,4-dihydroisoquinoline derivatives represented by general formula (1), comprising converting a compound represented by general formula (3) in the presence of acid after reacting with an aniline derivative, or converting a compound represented by general formula (3) by reacting with an aniline derivative in the presence of an acid.
Claims31
A method for producing a compound represented by general formula (1):
- wherein R1 and R2 independently represent an optionally substituted alkyl group having 1 to 6 carbon atoms or R1 and R2 together with the carbon atom to which they are bound form an optionally substituted cycloalkyl group having 3 to 10 carbon atoms, X represents a halogen atom, optionally substituted alkyl group having 1 to 6 carbon atoms or optionally substituted alkoxy group having 1 to 6 carbon atoms, n represents an integer of 0 to 4, Y represents a halogen atom, optionally substituted alkyl group having 1 to 6 carbon atoms or optionally substituted alkoxy group having 1 to 6 carbon atoms, and m represents an integer of 0 to 4, comprising reacting a compound represented by general formula (2):
- wherein R1, R2, X, Y, n and m are the same as previously defined, in the presence of an acid.
A method for producing a compound represented by general formula (1):
- wherein R1 and R2 independently represent an optionally substituted alkyl group having 1 to 6 carbon atoms or R1 and R2 together with the carbon atom to which they are bound form an optionally substituted cycloalkyl group having 3 to 10 carbon atoms, X represents a halogen atom, optionally substituted alkyl group having 1 to 6 carbon atoms or optionally substituted alkoxy group having 1 to 6 carbon atoms, n represents an integer of 0 to 4, Y represents a halogen atom, optionally substituted alkyl group having 1 to 6 carbon atoms or optionally substituted alkoxy group having 1 to 6 carbon atoms, and m represents an integer of 0 to 4, comprising reacting a compound represented by general formula (3):
- wherein R1, R2, X and n are the same as previously defined, with a compound represented by general formula (4):
- wherein Y and m are the same as previously defined, in the presence of an acid.
31-39. (canceled)
Dependencies are inferred from the claim text.