Novel compound having affinity for amyloid
AssigneeNihon Medi-Physics Co., Ltd.
InventorsYuki Okumura, Yoshifumi Maya, Yoshinari Shoyama, Takako Onishi
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Abstract
A compound that is effective as a diagnostic imaging probe that targets amyloid including is represented by the following formula (1), or salt thereof: wherein R1 is a radioactive halogen substituent, A1 and A2 independently represent CH or N. A diagnostic agent for Alzheimer's disease includes the compound represented by the above formula or a salt thereof. The above compound and the above diagnostic agent for Alzheimer's disease transfer into brain after administration, and indicate good accumulation on amyloid deposited in the brain.
Claims5
A compound represented by the following formula (1), or a salt thereof:
- wherein R1 is a radioactive halogen substituent, and A1 and A2 independently represent CH or N.
A compound represented by the following formula (2), or a salt thereof:
- wherein R2 is a group selected from the group consisting of a non-radioactive halogen substituent, nitro group, trialkylammonium group having alkyl chains with 1 to 4 carbon atoms, trialkylstannyl substituent having alkyl chains with 1 to 4 carbon atoms and triphenylstannyl group, and A3 and A4 independently represent CH or N.
A diagnostic agent for Alzheimer's disease, which comprises a compound represented by the following formula (1), or a salt thereof:
- wherein R1 is a radioactive halogen substituent, and A1 and A2 independently represent CH or N.
Dependencies are inferred from the claim text.