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US 2014/0228540 A1Published application
Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
AssigneeAmgen Inc.
InventorsRoy A. Black, Peng Li, Joshua Silverman
Life of this patent
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Abstract
The present invention relates to TIMP-3 binding compositions, methods of producing such compositions, and methods of using such compositions, including in the treatment of various conditions.
Claims5
1-9. (canceled)
A TIMP-3 binding protein that binds TIMP-3 and inhibits internalization of TIMP-3 by LRP-1 wherein the TIMP-3 binding protein is an LRP-1 peptide selected from the group consisting of LA24-25 (amino acids 3453-3535 of SEQ ID NO:1), LA 25-26 (amino acids 3594-3574 of SEQ ID NO:1) and LA24-26 (amino acids 3453-3574 of SEQ ID NO:1).
Dependencies are inferred from the claim text.