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US 2014/0228516 A1Published application
Bispecific intracellular delivery vehicles
AssigneesPhaseRx, Inc., University of Washington
InventorsPatrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Robert Overell, Paul Johnson
Life of this patent
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Abstract
A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
Claims21
1-47. (canceled)
A composition for delivering a therapeutic or diagnostic agent to a cell, comprising:
- a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer comprising a plurality of pendant linking groups,
- wherein the bispecific affinity reagent is a bispecific scFv.
Dependencies are inferred from the claim text.