Cationic pharmaceutically active ingredient containing composition, and methods for manufacturing and using

A method of using a cationic pharmaceutically active ingredient containing composition, the method comprises:

• (a) applying a cationic pharmaceutically active ingredient containing composition to skin tissue, the cationic pharmaceutically active ingredient containing composition comprising:
• (i) about 0.0001 wt. % to about 5 wt. % cationic pharmaceutically active ingredient;
• (ii) at least about 3 wt. % of a hydrophobic polymer/hydrophilic polymer adduct comprising a poly(vinylpyrrolidone-alkylene) polymer and a polymer comprising carboxylic acid groups, hydroxyl groups, or mixture of carboxylic acid groups and hydroxyl groups;
• (iii) a compatibilizing amount of a long chain organic acid having a carbon chain of at least about 8 carbon atoms;
• and
• (iv) at least about 50 wt. % water.

A method for manufacturing a cationic pharmaceutically active ingredient containing composition, the method comprising:

• (a) forming a polymer adduct comprising a poly (vinylpyrrolidone-alkylyne) polymer and a polymer comprising carboxylic acid groups, hydroxyl groups, or a mixture of carboxylic acid groups and hydroxyl groups. In the presence of less than one wt. percent water, if water is present at all;
• (b) forming an emulsion containing the polymer adduct and water, wherein the water is present in an amount of at least about 50 wt. %;
• and
• (c) adding a long chain organic acid having a carbon chain of at least about 8 carbon atoms and a cationic pharmaceutically active ingredient.