Compounds for treating ophthalmic diseases and disorders

A compound of Formula (I) or tautomer, stereoisomer, geometric isomer or a pharmaceutically acceptable salt or N-oxide thereof:

• wherein,
• Z is —C(R9)(R10)—C(R1)(R2)—;
• G is selected from —N(R42) C(═O)—R40, or —N(R42)—C(R42)(R42)—R40;
• R40 is selected from —C(R16)(R17)(R18);
• each R42 is hydrogen;
• R1 and R2 are each independently selected from hydrogen, halogen, C1-C5 alkyl;
• or R1 and R2 together form an oxo;
• R3 and R4 are each hydrogen;
• R9 and R10 are each independently selected from hydrogen, halogen, C1-C5 alkyl or —OR19;
• or
• R9 and R10 form an oxo;
• or optionally, R9 and R1 together form a direct bond to provide a double bond;
• or optionally, R9 and R1 together form a direct bond, and R10 and R2 together form a direct bond to provide a triple bond;
• R11 is hydrogen and R12 is hydrogen, —CH3, or —C(═O)R23;
• R23 is C1-C5 alkyl;
• R19 and R34 are each independently hydrogen or C1-C5 alkyl;
• R16 and R17 are each independently selected from hydrogen, C1-C5 alkyl, or halo;
• R18 is selected from hydrogen, C1-C5 alkyl, alkoxy, hydroxy, halo or fluoroalkyl;
• each R33 is independently selected from halogen, OR34, C1-C5 alkyl, or fluoroalkyl;
• and n is 0, 1, or 2.