Organ protection solution and its method of use
AssigneeVirginia Commonwealth University
InventorMartin MANGINO
Life of this patent
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Abstract
An organ protectant solution which is intravenously administered includes a high concentration of cell-impermeant molecules and at least one oncotic agent. The cell-impermeant molecules preferentially load into the interstitial space and the oncotic agent(s) is/are restricted to the vasculature space. Together, they promote transfer of water from cells to interstitium and into the capillaries, thereby preventing or reducing cell swelling, and maintaining blood circulation and oxygenation of tissues. The organ protectant solution extends the “Golden Hour” for traumatic and/or hemorrhagic shock patients, thereby allowing more time for those patients to reach a point of care facility to receive medical treatment.
Claims16
A method for prolonging low volume resuscitation in a subject in need thereof, with the steps of
- administering intravenously to said subject 2000 milliliters or less of an organ protectant solution comprising at least one of
- a) one or more cell impermeant molecules present at a concentration of at least 10-60% by weight, wherein at least one of said one or more cell impermeant molecules can cross a capillary endothelium and preferentially load into an extracellular fluid compartment in said subject and increase a theoretical extracellular fluid osmolarity without entering one or more of endothelial and parenchymal cells;
- and
- b) one or more oncotic agents present at a concentration of at least 1-10% by weight and with a molecular weight and size sufficient to restrict said one or more oncotic agents to a vascular space in said subject, wherein said one or more oncotic agents increase oncotic pressure and cause water to transfer from said interstitial space into said vascular space;
- and
- reducing cell swelling and promoting microcirculatory blood flow for at least 4 hours in said subject.
A method to treat severe hypotension in a subject by the step of
- administering intravenously a pharmaceutically acceptable organ protectant solution, comprising at least one impermeant molecule selected from the group of gluconate, raffinose and trehalose at a total concentration of 10% to 25% by weight, and at least one PEG polymer with a molecular weight of at least 20,000 at a concentration of 5% to 10% by weight, in an amount sufficient to raise blood pressure to at least 35 mmHg in said subject and extend a time period for low volume resuscitation to at least 4 hours.
An organ protectant solution, wherein each of gluconate, raffinose, and trehalose at 10-25% by weight, and polyethylene glycol polymers (PEG) with a molecular weight of at least 20,000 at a concentration of 1-10% by weight, and a pharmaceutically acceptable carrier are present in a single use infusion of no more than 2000 ml.
A method for protecting organs for transplantation, comprising the steps of
- administering to a DCD organ donor an organ protectant solution comprising at least one of
- a) one or more cell impermeant molecules present at a concentration of at least 10-60% by weight, wherein at least one of said one or more cell impermeant molecules can cross a capillary endothelium and preferentially load into an extracellular fluid compartment in said subject and increase a theoretical extracellular fluid osmolarity without entering one or more of endothelial and parenchymal cells;
- and
- b) one or more oncotic agents present at a concentration of at least 1-10% by weight and with a molecular weight and size sufficient to restrict said one or more oncotic agents to a vascular space in said subject, wherein said one or more oncotic agents increase oncotic pressure and cause water to transfer from said interstitial space into said vascular space;
- and
- maintaining circulation of said DCD organ donor for a suitable period of time, and removing surgically said organs of said DCD organ donor, and
- flushing said organs for cold storage or perfusion prior to said transplantation.
Dependencies are inferred from the claim text.