Targets for treatment of er stress
AssigneePresident and Fellows of Harvard College
InventorsGökhan S. Hotamisligil, Suneng Fu
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Abstract
The embodiments of the invention provide for genetic, chemical or dietary interventions that modulate hepatic phospholipid synthesis and/or endoplasmic reticulum (ER) calcium homeostasis function. More specifically, the present invention addresses modulation of the lipid composition of the hepatic stressed ER and/or improvement of the hepatic ER calcium metabolism to reduce ER stress and thus treat type 2 diabetes, fatty liver disease, atherosclerosis, inflammation, and/or dislipidemia.
Claims10
A method of treating hepatic chronic endoplasmic reticulum (ER) stress in an obese subject comprising modulating the phosphatidylcholine/phosphatidylethanolamine (PC/PE) ratio in the liver, wherein the subject is suffering from type 2 diabetes, dislipidemia, fatty liver disease, inflammation, or atherosclerosis;
- and wherein the correcting improves glucose homeostasis.
A method of treating hepatic chronic endoplasmic reticulum (ER) stress in an obese subject comprising modulating calcium homeostasis in the liver, wherein the subject is suffering from type 2 diabetes, lipodemia, fatty liver disease, inflammation, or atherosclerosis;
- and wherein the correcting improves glucose homeostasis.
Dependencies are inferred from the claim text.