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US 2014/0228415 A1Published application
Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo Efficacy
AssigneeNovartis AG
InventorsDavid Weninger BARNES, Dean Franklin RIGEL
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Abstract
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein X is defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.
Claims16
A compound of the formula (I):
- wherein:
- X is OH, O—C1-7alkyl or O—C6-10aryl;
- or a pharmaceutically acceptable salt thereof.
10-15. (canceled)
Dependencies are inferred from the claim text.