Fatty acid niacin conjugates and their uses

A compound of Formula II:

• or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, enantiomer or stereoisomer thereof;
• wherein
• R1, R2, and R3 are each independently selected from the group consisting of —H, -D, —Cl, —F, —CN, —NH2, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, —NH(C(O)C1-C3 alkyl), —N(C(O)C1-C3 alkyl)2, —C(O)H, —C(O)C1-C3 alkyl, —C(O)OC1-C3 alkyl, —C(O)NH2, —C(O)NH(C1-C3 alkyl), —C(O)N(C1-C3 alkyl)2, —C1-C3 alkyl, —O—C1-C3 alkyl, —S(O)C1-C3 alkyl, and —S(O)2C1-C3 alkyl;
• W1 and W2 are each independently selected from null, O, S, NH, and NR;
• each a, b, c, and d is independently —H, -D, Halogen, —CH3, —OCH3, —OCF3, —OCH2CH3, or —C(O)OR, —O—Z, or benzyl, or two of a, b, c, and d can be taken together along with the single carbon to which they are bound to form a cycloalkyl or heterocycle;
• each n, o, p, and q is independently 0 or 1;
• each L is independently —O—, —S—, —S(O)—, —S(O)2—, —S—S—,
• each g is independently 2, 3 or 4;
• each h is independently 1, 2, 3 or 4;
• each m is independently 0, 1, 2, or 3;
• if m is more than 1, then L can be the same or different;
• each m1 is independently 0, 1, 2, or 3;
• k is 0, 1, 2, or 3;
• each R6 is independently H or C1-C6 alkyl, or both R6 groups, when taken together with the nitrogen to which they are attached, can form a heterocycle;
• each R7 is independently e, H or straight or branched C1-C10 alkyl which can be optionally substituted with OH, NH2, CO2R, CONH2, phenyl, C6H4OH, imidazole or arginine;
• each e is independently H or any one of the side chains of the naturally occurring amino acids;
• each R9 is independently —H, -D, C1-C4 alkyl, halogen, cyano, oxo, thiooxo, —OH, C(O)C1-C4 alkyl, O-aryl, O-benzyl, OC(O)C1-C4 alkyl, C1-C3 alkene, C1-C3 alkyne, C(O)C1-C4 alkyl, NH2, NH(C1-C3 alkyl), N(C1-C3 alkyl)2, NH(C(O)C1-C3 alkyl), N(C(O)C1-C3 alkyl)2, SH, S(C1-C3 alkyl), S(O)C1-C3 alkyl, S(O)2C1-C3 alkyl;
• each Z is independently —H, or
• with the proviso that there is at least one
• each r is independently 2, 3, or 7;
• each s is independently 3, 5, or 6;
• each t is independently 0 or 1;
• each v is independently 1, 2, or 6;
• R4 and R5 are each independently hydrogen, deuterium, —C1-C4 alkyl, -halogen, —OH, —C(O)C1-C4 alkyl, —O-aryl, —O-benzyl, —OC(O)C1-C4 alkyl, —C1-C3 alkene, —C1-C3 alkyne, —C(O)C1-C4 alkyl, —NH2, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, —NH(C(O)C1-C3 alkyl), —N(C(O)C1-C3 alkyl)2, —SH, —S(C1-C3 alkyl), —S(O)C1-C3 alkyl, —S(O)2C1-C3 alkyl;
• and
• each R is independently —H or —C1-C3 alkyl;
• provided that
• when m, n, o, p, and q are each 0, W1 and W2 are each null, and Z is
• then t must be 0;
• and
• when each of m, n, o, p, and q is 0, and W1 and W2 are each null, then Z must not be